COMPARATIVE EVALUATION OF HEMATOPROTEKTIVE DICARBAMINE EFFICTIVENESS IN VARIOUS MODES AND IN DOSES IN CASE OF RADIATION DAMAGE OF THE BONE MARROW OF MICE

Zinovyev Alexander Ivanovich, Radiological practicioner of the regional oncologic dispensary, alivzi@yandex.ru
Moiseeva Inessa Yakovlevna, Doctor of medical sciences, professor, head of sub-department of general and clinical pharmacology, Medical Institute, Penza State University, moiseeva_pharm@mail.ru
Nebolsin Vladimir Evgenyevich, CEO, “Farminterprises” Ltd., nve1970@mail.ru

616.31-085

The article investigates dicarbamin influence on leukocytes formula of mice peripheral blood under circumstances of experimental bone marrow syndrome in various dosing regimens. The authors prove that the present drug in dosing interval from 5,0 to 50,0 mg/kg displays hepatoprotective effect by decreasing leukocytes falling depth by means of segmented neutrophiles and lymphocytes and restoring leukocytes recovery process to initial level. The most optimal dicarbamin dose is 15,0 mg/kg and the most optimal introduction way is oral.

dicarbamin, mice, irradiation, leukocytes formula of peripheral blood.